The Relationship between Salt Intake and Anti-Mog Levels in Patients with Neuromyelitis Optica Spectrum Disorder

Abstract

Background: Neuromyelitis optica Spectrum Disorder (NMOSD) is an inflammatory disorder of the central nervous system (CNS) that presents typically with relapses of optic neuritis or transverse myelitis. Antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. Previous studies demonstrated high salt intake may be associated with pro-inflammatory changes in the immune response, and increased clinical and magnetic resonance imaging (MRI) activity and aggravates T helper cell (Th17) responses and neuroinflammation in adults with multiple sclerosis.