Association of exposure to Bisphenol A with obesity and cardiometabolic risk factors in children and adolescents

(2019) Association of exposure to Bisphenol A with obesity and cardiometabolic risk factors in children and adolescents. International Journal of Environmental Health Research. pp. 94-106. ISSN 0960-3123

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Abstract

In this study, the association of exposure to Bisphenol A (BPA) with obesity and cardiometabolic risk factors was investigated on 132 children and adolescents aged 6-18years living in Isfahan, Iran. Potential contributors to BPA exposure were assessed by a questionnaire. Total BPA was detected in urine samples of all participants without significant difference in boys and girls.The mean body mass index (BMI) and waist circumference (WC) increased significantly across the BPA tertiles (p for trend=<0.001). Similar trend was documented for systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as fasting blood sugar. The risk of obesity was 12.48 times higher in participants in the third tertile of BPA than in others (95 CI: 3.36-46.39, p<0.001). The current study showed significant association between BPA exposure with obesity and some cardiometabolic risk factors in children and adolescents, however, further longitudinal studies are necessary to evaluate the clinical effects of this finding.Abbreviations: BMI: Body Mass Index; BPA: Bisphenol A; BSTFA: N, O-Bistrifluoroacetamide; CDC: Centers for Disease Control and Prevention; CI: Circumference Interval; DBP: Diastolic Blood Pressure; DLLME: Dispersive liquid-liquid microextraction method; FBS: Fasting Blood Glucose; HDL: high-density lipoprotein cholesterol were; LDL: low-density lipoprotein cholesterol; OR: Odd Ratio; PA: Physical Activity; SBP: Systolic Blood Pressure; TC: total cholesterol; TG: triglycerides; WC: Waist Circumference.

Item Type: Article
Keywords: bisphenol a obesity cardiometabolic risk factors children adolescents liquid-liquid microextraction chromatography-mass spectrometry human urine endocrine disruptors phthalate metabolites prevalence overweight dietary 4-nonylphenol extraction
Subjects: WS Pediatrics
WS Pediatrics > WS 405-460 By Age Groups
Divisions: Faculty of Health > Department of Environmental Health Engineering
Faculty of Health > Department of Epidemiology and Biostatistics
Faculty of Health > Student Research Committee
Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center
Research Institute for Primordial Prevention of Non-communicable Disease > Environment Research Center
Page Range: pp. 94-106
Journal or Publication Title: International Journal of Environmental Health Research
Journal Index: ISI
Volume: 29
Number: 1
Identification Number: https://doi.org/10.1080/09603123.2018.1515896
ISSN: 0960-3123
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/10430

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