(2019) Effects of pro-/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta-analysis. Complementary Therapies in Medicine. pp. 269-276. ISSN 1873-6963 (Electronic) 0965-2299 (Linking)
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Abstract
BACKGROUND & AIMS: Existing evidence on the possible effects of pro-/synbiotics on overweight or obese children and adolescents has not been fully established. Therefore, the present review was undertaken to evaluate the overall effects of pro-/synbiotics supplementation on anthropometric indices and metabolic indices in overweight or obese children and adolescents. METHODS: A systematic computerized literature search of PubMed, Scopus, ISI Web of science and Google Scholar databases was conducted up to November 2018. All RCTs using pro-/synbiotics supplements in overweight or obese children and adolescents included in this systematic review and meta-analysis. RESULTS: Overall 9 randomized trials including 410 subjects were identified for the present meta-analysis. Pooled analysis did not illustrate any significant changes in BMI z-score, waist circumference, weight, body fat, fasting blood sugar and lipid profiles (triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) after supplementation with pro-/synbiotics for 4-16 weeks. However, subgroup analysis by intervention type revealed a significant reduction of BMI z-score in synbiotic subgroups. CONCLUSION: Based on our findings, modulation of gut microbiota composition through pro-/ synbiotic supplements did not have favorable effects to manage overweight or obese children and adolescents. Further large-scale studies are warranted to confirm present findings.
Item Type: | Article |
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Keywords: | Children Meta-analysis Obesity Probiotic Synbiotic |
Subjects: | QU Biochemistry. Cell Biology and Genetics > QU 145-220 Nutrition. Vitamins WS Pediatrics |
Divisions: | Food Security Research Center School of Nutrition and Food Sciences > Department of Clinical Nutrition School of Nutrition and Food Sciences > Department of Community Nutrition School of Nutrition and Food Sciences > Student Research Committee |
Page Range: | pp. 269-276 |
Journal or Publication Title: | Complementary Therapies in Medicine |
Journal Index: | Pubmed |
Volume: | 44 |
Identification Number: | https://doi.org/10.1016/j.ctim.2019.05.008 |
ISSN: | 1873-6963 (Electronic) 0965-2299 (Linking) |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/10512 |
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