Ginseng treatment improves the sexual side effects of methadone maintenance treatment

(2019) Ginseng treatment improves the sexual side effects of methadone maintenance treatment. Psychiatry Res. pp. 142-150. ISSN 1872-7123 (Electronic) 0165-1781 (Linking)

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Abstract

BACKGROUND: While methadone maintenance therapy (MMT) in patients with opioid use disorder (OUD) decreases the risk of substance use relapses and criminal and risky sexual behavior, a major disadvantage is its negative impact on sexual function. In the present study we tested whether, compared to placebo, ginseng extract ameliorates methadone-related sexual dysfunction among female and male patients with OUD and receiving MMT. METHOD: A total of 74 patients (26 females: mean age: M=39.0 years; 48 males; mean age: 40.64 years) took part in a double-blind, randomized and placebo-controlled study. Female and male patients were separately randomly assigned either to the ginseng or to a placebo condition. At the beginning of the study and four weeks later, patients completed questionnaires on sexual function. RESULTS: Irrespective of gender, sexual function improved over time, but more so in the ginseng condition than in the placebo condition. CONCLUSIONS: Ginseng appears to counteract the sexual dysfunction resulting from methadone use in both female and male patients with OUD and undergoing MMT.

Item Type: Article
Keywords: Ginseng Methadone maintenance therapy Methadone-related sexual dysfunction Opioid use disorder
Subjects: QV Pharmacology
WL Nervous System
WM Psychiatry > WM 400-460.7 Therapies
Divisions: Isfahan Neurosciences Research Center
Page Range: pp. 142-150
Journal or Publication Title: Psychiatry Res
Journal Index: Pubmed
Volume: 276
Identification Number: https://doi.org/10.1016/j.psychres.2019.05.004
ISSN: 1872-7123 (Electronic) 0165-1781 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/10542

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