Gastroileostomy for controlling body weight and lipid profile: An experimental rat model

Abstract

Objective: there is a direct correlation between development of obesity and elevated lipid profile. Restrictive and malabsorptive mechanisms along with stimulating neuroendocrine signals are major components of current bariatric surgeries. Higher weight loss is achieved by a malabsorptive operation compare to other bariatric procedures. In this study, we aim to investigate the early effects of gastroileostomy on weight reduction and lipid profile in rat model. Materials and methods: Gastroileostomies with side-to-side anastomosis were performed on 15 male New Zealand rats. Blood samples were obtained at baseline and one week after the surgery. Blood samples were analyzed for lipid profiles. Results: The data showed that gastroileostomy leads to a significant decrease in weight (330 ± 15 vs. 240 ± 25 g before and after surgery, respectively; p = 0.04). The levels of triglycerides decreased in plasma (99.21 ± 29.012 mg/dl before and 95.64 ± 48.668 mg/dl after the surgery respectively; p = 0.807). Total cholesterol (71.14 ± 13.416 mg/dl vs. 72.64 ± 22.455 mg/dl; p = 0.813) and LDL (12.96 ± 4.853 mg/dl vs. 15.36 ± 5.665 mg/dl p = 0.121) had no significant changes after the operation. Conclusion: Based on the results of this study, gastroileostomy is effective for weight reduction but has no statistically significant change on lipid profiles in a short time. Therefore, this surgery is a promising surgery for weight reduction like other methods of bariatric surgery. © 2019 Elsevier Ltd