(2019) A luminescent biosensor for ex vivo detection of HER2-positive breast cancer based on a novel affiprobe. Analytical Methods. pp. 4233-4241. ISSN 1759-9660
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Abstract
A novel receptor tyrosine-protein kinase erbB-2 (HER2)-binding affiprobe - named Z(HER2:342)-RLuc - was designed, produced and assessed in terms of function to detect HER2 positive cells and for preliminary clinical diagnosis. The Z(HER2:342) affibody with affinity for HER2 was fused to Renilla luciferase, and the purified affiprobe was used for detection of HER2 positive cells as well as evaluation of surgical specimens from breast cancer patients. The results showed that the affiprobe can specifically bind to HER2 positive cells, and therefore, it may be used for molecular detection.
| Item Type: | Article |
|---|---|
| Keywords: | renilla luciferase affibody molecules primary tumors her2 expression antibody trastuzumab metastases xenograft antigen Chemistry Food Science & Technology Spectroscopy |
| Subjects: | QZ Pathology QZ Pathology > QZ 200-380 Neoplasms |
| Divisions: | Faculty of Medicine > Departments of Clinical Sciences > Department of Pathology |
| Page Range: | pp. 4233-4241 |
| Journal or Publication Title: | Analytical Methods |
| Journal Index: | ISI |
| Volume: | 11 |
| Number: | 33 |
| Identification Number: | https://doi.org/10.1039/c9ay01077g |
| ISSN: | 1759-9660 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/11298 |
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