Clinical and molecular assessment of 13 Iranian families with Wolfram syndrome

(2019) Clinical and molecular assessment of 13 Iranian families with Wolfram syndrome. Endocrine. pp. 185-191. ISSN 1355-008X

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Official URL: WOS:000509108100007

Abstract

Purpose Wolfram syndrome (WS) is a rare genetic disorder described by a pattern of clinical manifestations such as diabetes mellitus, diabetes insipidus, optic nerve atrophy, sensorineural hearing loss, urinary tract abnormalities, and psychiatric disorders. WFS1 and WFS2 loci are the main genetic loci associated with this disorder. Methods In the current study, we investigated associations between these loci and WS via STR markers and homozygosity mapping in 13 Iranian families with WS. All families were linked to WFS1 locus. Results Mutation analysis revealed four novel mutations (Q215X, E89X, S168Del, and E391Sfs*51) in the assessed families. Bioinformatics tools confirmed the pathogenicity of the novel mutations. Other identified mutations were previously reported in other populations for their pathogenicity. Conclusions The current study adds to the mutation repository of WS and shows a panel of mutations in Iranian population. Such panel would facilitate genetic counseling and prenatal diagnosis in families with WS cases.

Item Type: Article
Keywords: Wolfram Syndrome WFS1 diabetes-mellitus optic atrophy wfs1 gene deafness didmoad mutation phenotype neurodegeneration insipidus Endocrinology & Metabolism
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Research Institute for Primordial Prevention of Non-communicable Disease > Pediatric Inherited Diseases Research Center
Page Range: pp. 185-191
Journal or Publication Title: Endocrine
Journal Index: ISI
Volume: 66
Number: 2
Identification Number: https://doi.org/10.1007/s12020-019-02004-w
ISSN: 1355-008X
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/11454

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