Effects of phytosterols supplementation on blood pressure: A systematic review and meta-analysis

(2019) Effects of phytosterols supplementation on blood pressure: A systematic review and meta-analysis. Clin Nutr. ISSN 1532-1983 (Electronic) 0261-5614 (Linking)

Full text not available from this repository.

Abstract

Several reports have indicated a positive effect of phytosterols on blood pressure (BP), nevertheless these findings have been controversial. Therefore, a systematic review and meta-analysis of randomized controlled trials (RCTs) was aimed to investigate the effects of phytosterol supplementation on BP. An online search was carried out in PubMed, Scopus, ISI Web of Science, Cochrane library and Google Scholar up to May 2019. Weighted Mean difference (WMD) with 95 confidence intervals (CIs) were calculated using a fixed-effects model. The present meta-analysis of 19 RCTs showed that supplementation with phytosterols can decrease both systolic BP (WMD: -1.55 mmHg, 95 CI: -2.67 to -0.42, p = 0.007) and diastolic BP (WMD: -0.84 mmHg, 95 CI: -1.60 to -0.08, p = 0.03). Dose-response analysis revealed that phytosterol intake change SBP significantly based on treatment dose in nonlinear fashion. Subgroup analysis based on duration showed a significant effect of phytosterol on SBP and DBP in subsets of <12 weeks. In addition, a significant effect of phytosterol was observed in dosage of >/=2000 mg for SBP and <2000 mg for DBP. Based on current findings supplementation with phytosterol may be a beneficial adjuvant therapy in hypertensive patients as well as a complementary preventive option in prehypertensive and normotensive individuals. However, this issue is still open and requires further investigation in future studies.

Item Type: Article
Keywords: Blood pressure Meta-analysis Phytosterol Systematic review
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 145-220 Nutrition. Vitamins
WH Hemic and Lymphatic Systems > WH 120-540 Hematologic Diseases. Immunologic Factors. Blood Banks
Divisions: Food Security Research Center
School of Nutrition and Food Sciences > Department of Community Nutrition
Journal or Publication Title: Clin Nutr
Journal Index: Pubmed
Identification Number: https://doi.org/10.1016/j.clnu.2019.12.020
ISSN: 1532-1983 (Electronic) 0261-5614 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/11603

Actions (login required)

View Item View Item