The effect of cocoa consumption on markers of oxidative stress: A systematic review and meta-analysis of interventional studies

(2020) The effect of cocoa consumption on markers of oxidative stress: A systematic review and meta-analysis of interventional studies. Complement Ther Med. p. 102240. ISSN 1873-6963 (Electronic) 0965-2299 (Linking)

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Abstract

A number of studies have examined the beneficial effects of cocoa consumption on markers of oxidative stress in different population, however, the findings have been inconclusive. Herein, we systematically reviewed available interventional studies to elucidate the overall impact of cocoa consumption on markers of oxidative stress among adult population. PubMed, Cochrane's library, Science Direct, Scopus, Google scholar and ISI web of science databases were searched for all available literature until March 2019 for relevant studies. The Jadad scale was used to assess the quality of each study. A total of 48 studies out of 1402 met the inclusion criteria and were included in our systematic review and 16 of them were entered in meta-analysis. The pooled estimate from the random-effect model showed cocoa consumption significantly reduced malondialdehyde (SMD: -0.71; 95 CI, -1.41 to -0.01; P = 0.048) and 8-iso-prostaglandin F2alpha (WMD: -43.76; 95 CI, -76.25 to -11.28; P = 0.008) but not the other markers of oxidative stress. Our findings support the concept that cocoa consumption plays an important role in the human metabolic pathway through reducing the oxidative stress. In order to draw a firm link between cocoa and oxidative stress, more clinical trials with adequate sample size and sufficient follow-up periods are warranted.

Item Type: Article
Keywords: Cocoa Meta-analysis Oxidative stress Systematic review
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 145-220 Nutrition. Vitamins
Divisions: Food Security Research Center
School of Nutrition and Food Sciences > Department of Clinical Nutrition
School of Nutrition and Food Sciences > Department of Community Nutrition
School of Nutrition and Food Sciences > Student Research Committee
Page Range: p. 102240
Journal or Publication Title: Complement Ther Med
Journal Index: Pubmed, ISI
Volume: 48
Identification Number: https://doi.org/10.1016/j.ctim.2019.102240
ISSN: 1873-6963 (Electronic) 0965-2299 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/11672

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