The association of quantitative insulin sensitivity indices (HOMA-IR and QUICKI) with anthropometric and cardiometabolic indicators in adolescents

(2019) The association of quantitative insulin sensitivity indices (HOMA-IR and QUICKI) with anthropometric and cardiometabolic indicators in adolescents. Arch Med Sci Atheroscler Dis. e32-e37. ISSN 2451-0629 (Print) 2451-0629 (Linking)

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Abstract

Introduction: Homoeostasis model assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) are used to evaluate insulin resistance. The aim of this study was to investigate the association between quantitative insulin sensitivity indices and anthropometric and cardiometabolic indicators in adolescents. Material and methods: This descriptive-analytic cross-sectional study was conducted on 80 adolescents aged 12 to 13 years in Isfahan, Iran. Anthropometric, cardiometabolic and QUICKI and HOMA-IR indicators were measured. In the results analysis, Pearson correlation coefficient and regression analysis were used. Results: There was a significant positive correlation between most of the anthropometric indicators and the HOMA-IR index and a significant negative correlation with QUICKI (all p < 0.0001). Moreover, serum triglyceride level had a significant negative correlation with QUICKI index (R = -0.33, p = 0.002) and systolic blood pressure (R = 0.44, p < 0.0001), and triglyceride level (R = 0.66, p < 0.0001) had a significant positive correlation with HOMA index. The results of these two indices were highly correlated in most of the anthropometric and biochemical indices, except for the waist circumference to the neck circumference ratio and systolic blood pressure, which had a significant positive association with HOMA-IR, but did not show a significant association with QUICKI index. Conclusions: A significant correlation between anthropometric and cardiometabolic indicators with insulin resistance indices (HOMA-IR and QUICKI) was found. Moreover, the results of these two indices were highly correlated in most of the anthropometric and biochemical indices, except for the waist circumference to the neck circumference ratio and systolic blood pressure.

Item Type: Article
Keywords: Homa-ir Quicki anthropometric indices cardiometabolic indices
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 100-175 Nutrition Disorders
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 200-226 Metabolic Diseases
Divisions: Faculty of Health > Department of Epidemiology and Biostatistics
School of Nutrition and Food Sciences > Department of Community Nutrition
Page Range: e32-e37
Journal or Publication Title: Arch Med Sci Atheroscler Dis
Journal Index: Pubmed
Volume: 4
Identification Number: https://doi.org/10.5114/amsad.2019.84411
ISSN: 2451-0629 (Print) 2451-0629 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/11678

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