(2019) Prognostic significance of Fc receptor-like 1 in patients with chronic lymphocytic leukemia, hairy cell leukemia, and various B-cell non-Hodgkin's lymphoma. Leuk Res Rep. p. 100181. ISSN 2213-0489 (Print) 2213-0489 (Linking)
Full text not available from this repository.
Abstract
Fc receptor-like 1 (FCRL1) positively regulates B-cell responses and may involve in the pathogenesis of B-cell malignancies. This study examined the expression pattern of FCRL1 in B-cell non-Hodgkin's lymphoma patients using real-time PCR and flow cytometry. The results revealed higher levels of FCRL1 expression in diffuse large B-cell lymphoma, hairy cell leukemia, and Burkitt lymphoma patients compared with control groups. There was a significant reduction in the levels of FCRL1 expression in chronic lymphocytic leukemia and mantle cell lymphoma patients compared with healthy individuals. These findings suggest FCRL1 as an excellent marker for the prognosis or immunotherapy of B-cell malignancies.
| Item Type: | Article |
|---|---|
| Keywords: | B-cell non-Hodgkin's lymphoma Chronic lymphocytic leukemia Fc receptor-like 1 Hairy cell leukemia |
| Subjects: | QW Microbiology and Immunology > QW 501-949 Immunology |
| Divisions: | Cardiovascular Research Institute > Applied Physiology Research Center Faculty of Medicine > Department of Basic Science > Immunology Department |
| Page Range: | p. 100181 |
| Journal or Publication Title: | Leuk Res Rep |
| Journal Index: | Pubmed |
| Volume: | 12 |
| Identification Number: | https://doi.org/10.1016/j.lrr.2019.100181 |
| ISSN: | 2213-0489 (Print) 2213-0489 (Linking) |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/11822 |
Actions (login required)
 |
View Item |