(2019) Antidepressant-like effect of minocycline in mice forced swimming test: Minor involvement of the noradrenergic system. Thai Journal of Pharmaceutical Sciences. pp. 125-130. ISSN 01254685 (ISSN)
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Abstract
Introduction: Minocycline is a tetracycline antibiotic drug that is receiving attention as an alternative for the treatment of depression. Several mechanisms have been proposed for this effect. The current study evaluated the involvement of the noradrenergic system in the antidepressant-like effect of minocycline. Materials and Methods: The total immobility time was evaluated as an index of depression in mice forced swimming test (FST). Minocycline (40 mg/kg) was injected for 3 days. Imipramine (5 mg/kg, a tricyclic antidepressant), prazosin (1 mg/kg, an α1-adrenoceptor antagonist), yohimbine (1 mg/kg, an α2-adrenoceptor antagonist), and propranolol (2 mg/kg, a β-adrenoceptor antagonist) were injected 30 min before the last dose of minocycline, α-methyl-p-tyrosine (100 mg/kg, an inhibitor of tyrosine hydroxylase) was administered 4 h before minocycline final dose. Results: Minocycline decreased the immobility time during FST. The injection of prazosin prevented the anti-depressant like effect of minocycline, while imipramine, yohimbine or propranolol potentiates the anti-depressant like effect of minocycline during the FST. Besides that, the pretreatment of mice with α-methyl-p-tyrosine did not change the minocycline antidepressant-like effect in the FST. Conclusion: The present study suggests that the noradrenergic system has a trivial role in the antidepressant-like effect of minocycline; the impact on neuroinflammation and cytokines might be more important. © 2019, Faculty of Pharmaceutical Sciences, Chulalongkorn University. All rights reserved.
Item Type: | Article |
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Keywords: | Adrenoceptor Depression Forced swimming test Minocycline Noradrenergic system imipramine metirosine prazosin propranolol yohimbine animal experiment animal model antidepressant activity Article controlled study drug efficacy forced swim test immobility time male mouse nonhuman sucrose preference test |
Subjects: | QV Pharmacology |
Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > Department of Toxicology and Pharmacology Isfahan Pharmaceutical Sciences Research center |
Page Range: | pp. 125-130 |
Journal or Publication Title: | Thai Journal of Pharmaceutical Sciences |
Journal Index: | Scopus |
Volume: | 43 |
Number: | 3 |
ISSN: | 01254685 (ISSN) |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/11918 |
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