The effect of Vitamin D supplement on outcomes in patients with traumatic injuries hospitalized in intensive care unit: A clinical trial study

Abstract

Background: As published in literature, vitamin D deficiency lead to increased morbidity and mortality rate in patients who hospitalized in intensive care units (ICUs). The present study conducted to evaluate the effect of vitamin D supplement on outcomes in patients with traumatic injuries hospitalized in ICU. Methods: In a clinical trial study, 55 patients with low levels of vitamin D (less than 30 ng/ml) and 55 patients with normal levels of vitamin D were selected from the patients admitted to the ICU of Alzahra hospital, Isfahan, Iran. The patients suffering hypovitaminosis D (interventional group) received 300,000 units of vitamin D intramuscularly. Patients who had adequate vitamin D levels were considered as control group. The patients' recovery from the ICU was evaluated and compared by the Sequential Organ Failure Assessment (SOFA) index. Findings: SOFA scores were significantly higher in vitamin D deficiency group in first 2 weeks after hospitalization. Serum vitamin D levels at the end of the 3rd week had no statistical different between the two groups. The discharge rate in vitamin D deficiency group in first 2 weeks were lower than control group significantly. But at the end of the third week, the difference between the two groups was not significant. Conclusion: The results of our study showed that vitamin D supplement increased discharge rate of traumatic patients hospitalized in ICU. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.