Complications of therapeutic plasma exchange in patients with neurological disorders

(2020) Complications of therapeutic plasma exchange in patients with neurological disorders. Current Journal of Neurology. pp. 8-12. ISSN 2717-011X

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Abstract

Background: Therapeutic plasma exchange (TPE) is the treatment of choice for many neurologic disorders. The safety of this procedure is a major concern for physicians. The aim of this study was to determine the complications of TPE in patients with neurologic disorders at a tertiary referral hospital. Methods: This retrospective cross-sectional study evaluated patients with various neurologic disorders receiving TPE in neurology department of Shariati Hospital, Tehran, Iran. Major and minor complications related to TPE were recorded. Results: Clinical information records of 417 TPE sessions (88 patients) were available. Mean age of patients was 40.0 +/- 15.8 years. Underlying diseases included central demyelinating disorders, myasthenia gravis (MG), chronic neuropathy, Guillain-Barre syndrome (GBS), and autoimmune encephalopathy in 34.1, 33.0, 17.0, 14.8, and 1.1 of patients, respectively. Major complications occurred in 15.9 of patients and 37.5 of patients accounted for minor complications. Among major adverse effects, thrombosis, infection, and life-threatening complications were seen more commonly in patients with central vascular access (P = 0.005, P = 0.003, and P = 0.010, respectively). Conclusion: TPE complications were seen more commonly in patients with central vascular access. Therefore, use of peripheral vascular access and vigilant patient monitoring by trained health providers can reduce its complications.

Item Type: Article
Keywords: Plasma Exchange Plasmapheresis Nervous System Diseases PLASMAPHERESIS APHERESIS
Subjects: WL Nervous System > WL 140-160 Diseases. Examination and Diagnosis (General)
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Neurology
Page Range: pp. 8-12
Journal or Publication Title: Current Journal of Neurology
Journal Index: ISI
Volume: 19
Number: 1
ISSN: 2717-011X
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12052

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