Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial

(2020) Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial. Journal of Interferon and Cytokine Research. pp. 262-267. ISSN 1079-9907

Full text not available from this repository.

Abstract

Environmental exposure to diesel particulate matter and commercial gasoline in gas station workers might induce oxidative stress and changes in the balance of the immune system. In this study, the immunomodulatory impacts of omega 3 fatty acid (omega 3FA) supplement were assessed on inflammatory and anti-inflammatory markers in gas station workers in a double-blind placebo-controlled clinical trial. Fifty-three men working in gas stations were treated with omega 3FA (n = 29) or placebo (n = 24) for 60 days. C-reactive protein, interleukin-12 (IL-12), transforming GRAPHICS growth factor beta (TGF-beta), interferon gamma (IFN-gamma), tumor necrosis factor alpha, IL-10, and IL-17 levels were measured by enzyme-linked immunosorbent assay method before and after the completion of the trial. The concentrations of IFN-gamma and IL-17 were significantly decreased in omega 3FA group compared with the placebo group (P < 0.001). Moreover, the levels of inhibitory cytokines including TGF-beta and IL-10 significantly were increased in omega 3FA group (P < 0.001). Overall, omega 3FA nutritional supplementation can be useful in reducing inflammatory immune responses and maintaining immune tolerance in people with high exposure to inflammation-inducing factors.

Item Type: Article
Keywords: omega 3 inflammation C-reactive protein interleukin-12 interleukin-10 tumor necrosis factor-alpha interferon-gamma NECROSIS-FACTOR-ALPHA C-REACTIVE PROTEIN AIR-POLLUTION OMEGA-3-FATTY-ACID SUPPLEMENTATION DIESEL EXHAUST PARTICULATE MATTER OXIDATIVE STRESS DIETARY OMEGA-3 GENE-EXPRESSION SERUM-LEVELS
Subjects: WA Public Health > WA 670-847 Environmental Pollution. Sanitation
Divisions: Faculty of Health > Department of Epidemiology and Biostatistics
Faculty of Medicine > Department of Basic Science > Immunology Department
Faculty of Medicine > Student Research Committee
Isfahan Neurosciences Research Center
Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center
Research Institute for Primordial Prevention of Non-communicable Disease > Environment Research Center
Page Range: pp. 262-267
Journal or Publication Title: Journal of Interferon and Cytokine Research
Journal Index: ISI
Volume: 40
Number: 5
Identification Number: https://doi.org/10.1089/jir.2019.0220
ISSN: 1079-9907
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12296

Actions (login required)

View Item View Item