Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial

(2020) Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial. Asian Pac J Cancer Prev. pp. 255-258. ISSN 1513-7368 (Print) 1513-7368

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Abstract

BACKGROUND: Paraoxonase 1 (PON1), a multifactorial antioxidant enzyme, has a defensive role against oxidative stress, which is believed to contribute to cancer development. This study aimed to investigate the association of PON1-L55M functional polymorphism with breast cancer risk. MATERIAL AND METHODS: In the experimental study, blood samples were collected from 150 healthy women controls and 150 breast cancer subjects. The L55M genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Our analysis showed that the genotypes distribution is in Hardy-Weinberg equilibrium for both case and control groups. Our data revealed that there are significant associations between PON1-L55M polymorphism and breast cancer risk in homozygote (OR= 2.13, 95CI= 1.14-4.00, p= 0.018), dominant (OR= 1.72, 95CI= 1.07-2.76, p= 0.024), and allelic (OR= 1.55, 95CI= 1.12-2.15, p= 0.008) models. CONCLUSIONS: Our results suggest that the PON1-L55M genetic variation could be a genetic risk factor for breast cancer risk and it could be considered as a molecular biomarker for screening of susceptible women.<br />.

Item Type: Article
Keywords: Aryldialkylphosphatase/*genetics Biomarkers, Tumor/*genetics Breast Neoplasms/genetics/*pathology Carcinoma, Ductal, Breast/genetics/*secondary Carcinoma, Lobular/genetics/*secondary Case-Control Studies Female Follow-Up Studies *Genetic Predisposition to Disease Genotype Humans Lymphatic Metastasis Middle Aged Neoplasm Invasiveness Polymorphism, Genetic Prognosis Risk Factors Genetic polymorphism Pcr-rflp Paraoxonase 1 breast cancer
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QZ Pathology > QZ 200-380 Neoplasms
WP Gynecology and Obstetrics > WP 800-910 Breast
Divisions: Faculty of Medicine
Other
Page Range: pp. 255-258
Journal or Publication Title: Asian Pac J Cancer Prev
Journal Index: Pubmed
Volume: 21
Number: 1
Identification Number: https://doi.org/10.31557/apjcp.2020.21.1.255
ISSN: 1513-7368 (Print) 1513-7368
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12515

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