Magnesium Increases the Protective Effect of Citicoline on Aluminum Chloride-induced Cognitive Impairment

(2020) Magnesium Increases the Protective Effect of Citicoline on Aluminum Chloride-induced Cognitive Impairment. Clinical Psychopharmacology and Neuroscience. pp. 241-248. ISSN 1738-1088

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Abstract

Objective: Alzheimer's disease is a popular neurodegenerative disorder which is growing in the elderly people. Exposure to environmental pollutant like aluminum could trigger or accelerate its involved mechanisms like tau phosphorylation. The current study will evaluate the effect of alone or co-administration of Citicoline or/and magnesium on the aluminum chloride induced memory impairment. Methods: Male albino mice were randomly divided into different groups (n = 7). Memory impairment was induced via orally administration of 300 mg/kg Aluminum Chloride for 28 days. Based on respective group, animals received 100, 250, 500 mg/kg of Citicoline or 50, 100, 150 mg/kg of Magnesium sulfate (MgSO4), intraperitoneally. In co-admin-istration, 50 mg/kg of MgSO4 injected concomitantly with 100, 250, or 500 mg/kg of Citicoline. Rivastigmine (2 mg/kg intraperitoneally) was used as a positive control. Memory was evaluated using the Object Recognition Task (ORT) and Passive Avoidance Test (PAT). Results: The studied doses of Citicoline or MgSO4 when administered individually showed significant increase in the discrimination index in ORT and latency time in the PAT compared to the Aluminium chloride (AIC13) treated group. Concomitant injection of 50 mg/kg MgSO4 with the different doses of Citicoline strongly increased the above indices values in comparison to each alone. Conclusion: The findings show, individual administration of Citicoline or MgSO4 inverted the AlCl3-induced memory impairment in a dose independent manner. The addition of MgSO4 to the Citicoline showed a synergistic effect in the PAT and likely additive effect in the ORT.

Item Type: Article
Keywords: Citicoline Magnesium Aluminum chloride Memory Mice ACUTE ISCHEMIC-STROKE ALZHEIMERS-DISEASE RAT MODEL BRAIN MEMORY PATHOGENESIS TOXICITY MECHANISMS SYSTEM
Subjects: QV Pharmacology > QV 120-140 Autonomic Agents. Nonmetallic Elements. Neuromuscular Agents
WL Nervous System
Divisions: Faculty of Pharmacy and Pharmaceutical Sciences > Department of Toxicology and Pharmacology
Isfahan Pharmaceutical Sciences Research center
Page Range: pp. 241-248
Journal or Publication Title: Clinical Psychopharmacology and Neuroscience
Journal Index: ISI
Volume: 18
Number: 2
Identification Number: https://doi.org/10.9758/cpn.2020.18.2.241
ISSN: 1738-1088
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12775

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