Bilateral Retrobulbar Optic Neuritis as the First Manifestation of Neuro-Behçet Disease

(2020) Bilateral Retrobulbar Optic Neuritis as the First Manifestation of Neuro-Behçet Disease. Case Rep Rheumatol. p. 8834399. ISSN 2090-6889 (Print) 2090-6897

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Abstract

BACKGROUND: Behçet disease (BD) is a polygenic and chronic autoinflammatory multisystem vasculitis. Acute optic neuritis has been rarely reported in patients with BD, especially in children. Case Presentation. We reported an 8-year-old girl with a sudden visual loss and color vision impairment. The patient had a history of recurrent oral aphthous ulcers, genital ulcers, and chronic abdominal pain. On ophthalmic examination, anterior and posterior chambers and funduscopy of both eyes were normal. The results of laboratory tests for infectious and rheumatic diseases were normal. Brain magnetic resonance imaging and the result of cerebrospinal fluid analysis for oligoclonal bands and auto-antibodies were also normal. Pathergy skin test and human leukocyte antigens (HLA) B5 and HLA-B51 were positive. The patient was recognized as a case of BD-related bilateral retrobulbar optic neuritis and was treated by corticosteroids, azathioprine, colchicine, and infliximab. CONCLUSION: Retrobulbar optic neuritis may be the first manifestation of neuro-BD.

Item Type: Article
Keywords: Retrobulbar optic neuritis may be the first manifestation of neuro-BD.
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Pediatrics
Other
Page Range: p. 8834399
Journal or Publication Title: Case Rep Rheumatol
Journal Index: Pubmed
Volume: 2020
Identification Number: https://doi.org/10.1155/2020/8834399
ISSN: 2090-6889 (Print) 2090-6897
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12845

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