What are the effects of IL-1 beta (rs1143634), IL-17A promoter (rs2275913) and TLR4 (rs4986790) gene polymorphism on the outcomes of infection with H. pylori within as Iranian population; A systematic review and meta-analysis

Abstract

Helicobacter pylori (H. pylori) is one of the most important etiologic agents for peptic ulcer and gastric cancer. Since < 25 of H. pylori infected people have gastrointestinal disorders, the precise molecular mechanisms of H. pylori pathogenesis have not been identified. Despite the above explanation, studies have demonstrated that infection with H. pylori leads to the formation of active chronic gastritis lesions, which in turn can progress to acute gastritis, peptic ulcer or gastric atrophy, and ultimately gastric cancer. Depending on several factors such as bacterial virulence factors, immune response, host genetic and other conditions such as gastric acid secretion and type of nutrition, the pathologic effects of this bacterium can be different. Recent studies have shown that the single nucleotide polymorphisms (SNPs) have a critical role in the alternation of body responses and play a pivotal role in the outcomes of H. pylori infection. However, due to their prominent role in immune-pathogenesis of this bacterium, SNPs of IL-1 beta, IL-17A promoter and TLR4 genes has been extensively considered and can be regarded as a prognostic factor for susceptibility to peptic ulcer or gastric cancer diseases. In the present study, a meta-analysis was performed on the information of 1307 Iranian patients with gastritis, peptic ulcers and gastric cancer to determine the role of each of the SNPs in the formation of peptic ulcers and gastric cancer.