The interplay of endothelial dysfunction, cardiovascular disease, and cancer: What we should know beyond inflammation and oxidative stress

Abstract

Dear Editor in Chief of the European Journal of Preventive Cardiology With great enthusiasm, we read the well-conducted study by Toya et al.,1 entitled “Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer”, which was recently published in the European Journal of Preventive Cardiology. It has been well-demonstrated that microvascular dysfunction predicts and predisposes future cardiovascular disease. In the present study, Toya et al. provide us with important data, demonstrating that microvascular endothelial dysfunction, measured by reactive hyperemia peripheral arterial tonometry, signals the increased risk of incident solid-tumor cancer. This study further expands our previously published article,2 raising the issue that cardiovascular disease and cancer not only share modifiable risk factors like diet, sedentary lifestyle, obesity, and tobacco use, but also cellular, signaling, and genetic pathways that are central to the pathogenesis of both diseases