Risk of diabetes according to the metabolic health status and degree of obesity

(2017) Risk of diabetes according to the metabolic health status and degree of obesity. Diabetes & Metabolic Syndrome-Clinical Research & Reviews. S439-S444. ISSN 1871-4021

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Abstract

Aim: To determine the progression rates from metabolically healthy or unhealthy normal weight, overweight and obese phenotype to type 2 diabetes (T2D) in a non-diabetic high risk population in Isfahan, Iran. Methods: T2D incidence during a mean (SD) follow-up of 10.1 (2.3) years was examined among 1,982 non-diabetic first-degree relatives (FDR) of patients with T2D 30-70 years old. Participants were divided into 6 groups based on body mass index and metabolic syndrome component, except waist circumference, at baseline: metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW) and metabolically unhealthy obese (MUO). Results: The MHO, MUOW, and MUO individuals at baseline were associated with incidence of T2D, independently of age and gender. MHO were 3 times (OR 2.96; 95 CI 1.07, 8.24) and MUOW were 2.75 times (95 CI 1.17, 6.45) more likely to develop T2D than those with MHNW. There was excess risk in MUO than MHO (OR 3.86; 95 CI 1.64, 9.11). Conclusions: Obesity was a risk factor for T2D, even in the absence of any metabolic abnormalities. Metabolic abnormalities were a stronger predictor of incident T2D than obesity. (C) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: type 2 diabetes metabolically healthy obese metabolic syndrome obesity first-degree relatives incidence risk factor middle-aged men body-mass index cardiovascular-disease normal-weight individuals prevalence metaanalysis overweight profile impact
Divisions: Isfahan Endocrine and Metabolism Research Center
Other
Page Range: S439-S444
Journal or Publication Title: Diabetes & Metabolic Syndrome-Clinical Research & Reviews
Journal Index: ISI
Volume: 11
Identification Number: https://doi.org/10.1016/j.dsx.2017.03.032
ISSN: 1871-4021
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/132

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