The reno-protective role of Angiotensin 1-7 in Cisplatin induced nephrotoxicity

Abstract

Objective: To determine the protective role of angiotensin 1-7 (Ang1-7) against Cisplatin (CP) induced nephrotoxicity Design: Case-control animal experimental study Setting: Water and Electrolytes Research Center/Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran Subjects: 35 male (331 +/- 7.4 g) and female (196.5 +/- 5.9 g) Wistar rats Interventions: The rats were subject to treatment with vehicle, single dose of CP alone (7.5 mg/kg) or a single dose of CP plus daily infusion of Ang1-7 (30 mu g/kg/day). The measurements were performed one week after CP administration. Main outcome measures: Serum levels of blood urea nitrogen (BUN), creatinine (Cr) and malondialdehyde, kidney tissue damage score and normalized kidney weight Results: The increased kidney tissue damage, kidney weight, and the serum levels of BUN and Cr induced by CP was attenuated significantly by Ang1-7 (P<.05) in male rats. However, the protective role of Ang1-7 against CP induced nephrotoxicity was not detected in female rats. Conclusion: Ang1-7 may act as suitable supplement to attenuate CP induced nephrotoxicity in male rats, possibly due to its effect on kidney circulation.