(2020) Bleeding symptoms in patients diagnosed as type 3 von Willebrand disease: Results from 3WINTERS-IPS, an international and collaborative cross-sectional study. Journal of Thrombosis and Haemostasis. pp. 2145-2154. ISSN 15387933 (ISSN)
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Abstract
Background: Type 3 von Willebrand's disease (VWD) patients present markedly reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding phenotype of type 3 VWD is poorly described, as compared to type 1 VWD. Aims: To evaluate the frequency and the severity of bleeding symptoms across age and sex groups in type 3 patients and to compare these with those observed in type 1 VWD patients to investigate any possible clustering of bleeding symptoms within type 3 patients. Methods: We compared the bleeding phenotype and computed the bleeding score (BS) using the MCMDM-1VWD bleeding questionnaire in patients enrolled in the 3WINTERS-IPS and MCMDM-1VWD studies. Results: In 223 unrelated type 3 VWD patients, both the BS and the number of clinically relevant bleeding symptoms were increased in type 3 as compared to type 1 VWD patients (15 versus 6 and 5 versus 3). Intracranial bleeding, oral cavity, hemarthroses, and deep hematomas were at least five-fold over-represented in type 3 VWD. A more severe bleeding phenotype was evident in patients having von Willebrand factor antigen levels < 20 IU/dL at diagnosis in the two merged cohorts. In type 3 patients, there was an apparent clustering of hemarthrosis with gastrointestinal bleeding and epistaxis, whereas bleeding after surgery or tooth extraction clusters with oral bleeding and menorrhagia. Conclusions: In the largest cohort of type 3 VWD patients, we were able to describe a distinct clinical phenotype that is associated with the presence of a more severe hemostatic defect. © 2020 International Society on Thrombosis and Haemostasis
Item Type: | Article |
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Keywords: | type 1 epidemiology hemorrhage blood coagulation disorders type 3 von Willebrand disease von Willebrand disease antigen unclassified drug von Willebrand factor von Willebrand factor antigen adult Article bleeding score brain hemorrhage cohort analysis controlled study cross-sectional study disease association disease severity epistaxis female gastrointestinal hemorrhage hemarthrosis hematoma human informed consent major clinical study male menorrhagia oral bleeding phenotype postoperative period priority journal prospective study questionnaire scoring system tooth extraction Cross-Sectional Studies Humans von Willebrand Disease, Type 1 von Willebrand Disease, Type 3 von Willebrand Diseases |
Subjects: | WH Hemic and Lymphatic Systems > WH 120-540 Hematologic Diseases. Immunologic Factors. Blood Banks |
Divisions: | Other |
Page Range: | pp. 2145-2154 |
Journal or Publication Title: | Journal of Thrombosis and Haemostasis |
Journal Index: | Scopus |
Volume: | 18 |
Number: | 9 |
Identification Number: | https://doi.org/10.1111/jth.14886 |
ISSN: | 15387933 (ISSN) |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/13823 |
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