Evaluation of the anti-tuberculosis and cytotoxic potential of the seaweed Padina australis

(2020) Evaluation of the anti-tuberculosis and cytotoxic potential of the seaweed Padina australis. Iranian Journal of Pharmaceutical Sciences. pp. 29-38. ISSN 17352444 (ISSN)

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Abstract

Marine seaweeds synthesize different types of compounds with various biological activities, including anti-tuberculosis and anticancer effects. The aim of this study was to evaluate anti tuberculosis of Padina australis and cytotoxicity of different fractions of this seaweed. Padinaaustralis was collected from Persian Gulf, identified and extracted by maceration with methanol-ethyl acetate. The extract was evaporated and partitioned by Kupchan method to yield Hexane, dichloromethane, Butanol and water partitions. The anti-tuberculosis activity of the crude extract and cytotoxicity of fractions were investigated using GFPMA and MTT methods. The cell survivals of HeLa cell were decreased by increasing the concentration of extracts. The IC50 value of hexane, dichloromethane, butanol and water partitions were 2.0, 20, 19.7, and 182.7μg/ml, respectively. The crude extract was not active against tuberculosis. This study reveals that different partitions of Padina australis have cytotoxic activity against cancer cell lines. © 2020, Iranian Association of Pharmaceutical Scientists. All rights reserved.

Item Type: Article
Keywords: Cytotoxic Padina Persian Gulf Tuberculosis algal extract cytotoxic agent ethambutol isoniazid ofloxacin Padina australis extract rifampicin streptomycin tuberculostatic agent unclassified drug antibiotic sensitivity Article brown alga cell viability colony forming unit controlled study cytotoxicity cytotoxicity assay electroporation HeLa cell line human human cell HUVEC cell line IC50 minimum inhibitory concentration MRC-5 cell line Mycobacterium tuberculosis Padina australis seaweed
Subjects: QV Pharmacology
Divisions: Cardiovascular Research Institute > Applied Physiology Research Center
Cardiovascular Research Institute > Isfahan Cardiovascular Research Center
Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy
Isfahan Pharmaceutical Sciences Research center
Page Range: pp. 29-38
Journal or Publication Title: Iranian Journal of Pharmaceutical Sciences
Journal Index: Scopus
Volume: 15
Number: 1
ISSN: 17352444 (ISSN)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13848

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