(2020) Association between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study. Arch Physiol Biochem. pp. 1-7. ISSN 1381-3455
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Abstract
BACKGROUND: The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL). METHODS: A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method. RESULTS: There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p > .05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p > .05). However, patients group had higher level of sd-LDL compared to controls (p < .05). CONCLUSION: FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis.
| Item Type: | Article |
|---|---|
| Keywords: | Atherosclerosis C-reactive protein fatty acid-binding protein 2 small dense-LDL |
| Subjects: | QU Biochemistry. Cell Biology and Genetics |
| Divisions: | Faculty of Medicine > Departments of Clinical Sciences > Department of Internal |
| Page Range: | pp. 1-7 |
| Journal or Publication Title: | Arch Physiol Biochem |
| Journal Index: | Pubmed |
| Identification Number: | https://doi.org/10.1080/13813455.2020.1817097 |
| ISSN: | 1381-3455 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/13863 |
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