Emerging Technologies for the Treatment of COVID-19

(2021) Emerging Technologies for the Treatment of COVID-19. Adv Exp Med Biol. pp. 81-96. ISSN 0065-2598 (Print) 0065-2598

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Abstract

The new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), turned into a pandemic affecting more than 200 countries. Due to the high rate of transmission and mortality, finding specific and effective treatment options for this infection is currently of urgent importance. Emerging technologies have created a promising platform for developing novel treatment options for various viral diseases such as the SARS-CoV-2 virus. Here, we have described potential novel therapeutic options based on the structure and pathophysiological mechanism of the SARS-CoV-2 virus, as well as the results of previous studies on similar viruses such as SARS and MERS. Many of these approaches can be used for controlling viral infection by reducing the viral damage or by increasing the potency of the host response. Owing to their high sensitivity, specificity, and reproducibility, siRNAs, aptamers, nanobodies, neutralizing antibodies, and different types of peptides can be used for interference with viral replication or for blocking internalization. Receptor agonists and interferon-inducing agents are also potential options to balance and enhance the innate immune response against SARS-CoV-2. Solid evidence on the efficacy and safety of such novel technologies is yet to be established although many well-designed clinical trials are underway to address these issues.

Item Type: Article
Keywords: *Covid-19 *Coronavirus Infections/drug therapy Humans *Middle East Respiratory Syndrome Coronavirus/genetics Pandemics Reproducibility of Results SARS-CoV-2 Biotechnology Covid-19 Coronavirus Treatment
Page Range: pp. 81-96
Journal or Publication Title: Adv Exp Med Biol
Journal Index: Pubmed
Volume: 1321
Identification Number: https://doi.org/10.1007/978-3-030-59261-5₇
ISSN: 0065-2598 (Print) 0065-2598
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13967

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