Nanobased Platforms for Diagnosis and Treatment of COVID-19: From Benchtop to Bedside

(2021) Nanobased Platforms for Diagnosis and Treatment of COVID-19: From Benchtop to Bedside. Acs Biomaterials Science & Engineering. pp. 2150-2176. ISSN 2373-9878

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Abstract

Human respiratory viral infections are the leading cause of morbidity and mortality around the world. Among the various respiratory viruses, coronaviruses (e.g., SARS-CoV-2) have created the greatest challenge and most frightening health threat worldwide. Human coronaviruses typically infect the upper respiratory tract, causing illnesses that range from common cold-like symptoms to severe acute respiratory infections. Several promising vaccine formulations have become available since the beginning of 2021. Nevertheless, achievement of herd immunity is still far from being realized. Social distancing remains the only effective measure against SARS-CoV-2 infection. Nanobiotechnology enables the design of nanobiosensors. These nanomedical diagnostic devices have opened new vistas for early detection of viral infections. The present review outlines recent research on the effectiveness of nanoplatforms as diagnostic and antiviral tools against coronaviruses. The biological properties of coronavirus and infected host organs are discussed. The challenges and limitations encountered in combating SARS-CoV-2 are highlighted. Potential nanodevices such as nanosensors, nanobased vaccines, and smart nanomedicines are subsequently presented for combating current and future mutated versions of coronaviruses.

Item Type: Article
Keywords: COVID-19 coronavirus nanobiosensor nanobased vaccine SARS-CoV-2 ACUTE RESPIRATORY SYNDROME EPIDEMIC DIARRHEA VIRUS CRITICALLY-ILL PATIENTS FIELD-EFFECT TRANSISTOR REDUCED GRAPHENE OXIDE RAPID DETECTION SARS CORONAVIRUS GOLD NANOPARTICLES SPIKE PROTEIN CELL ENTRY
Page Range: pp. 2150-2176
Journal or Publication Title: Acs Biomaterials Science & Engineering
Journal Index: ISI
Volume: 7
Number: 6
Identification Number: https://doi.org/10.1021/acsbiomaterials.1c00318
ISSN: 2373-9878
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/14169

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