(2021) Inhibition of aldehyde dehydrogenase by furazolidone nanoemulsion to decrease cisplatin resistance in lung cancer cells. Therapeutic Delivery. pp. 611-625. ISSN 2041-5990
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Abstract
Aim: The overexpression of aldehyde dehydrogenase (ALDH) in cancer cells contributes to therapeutic resistance. Furazolidone (FUR) is a strong ALDH inhibitor. Methods: FUR nanoemulsion (NE) was formulated and tested for ALDH inhibitory activity in comparison with free FUR. The cytotoxic potential of cisplatin was evaluated in combination with free FUR and FUR NE. Results: The optimized FUR NE showed droplet size of 167.9 +/- 3.1 nm and drug content of 84.2 +/- 2.3. FUR NE inhibited 99.75 +/- 2.1 of ALDH activity while 25.0 +/- 4.6 was inhibited by free FUR. FUR NE increased the sensitivity to cisplatin in A549 cells by more than tenfold by its ALDH inhibitory effects. Conclusion: This finding can be a promising approach to improve cancer survival in ALDH-positive drug-resistant cancers.
| Item Type: | Article |
|---|---|
| Keywords: | aldehyde dehydrogenase cisplatin Furazolidone nanoemulsion sensitivity SOLID LIPID NANOPARTICLES BREAST-CANCER DRUG-DELIVERY 1A1 ALDH1A1 BIOAVAILABILITY EXPRESSION DESIGN POLOXAMINE-908 POLOXAMER-407 CHEMOTHERAPY |
| Subjects: | QV Pharmacology > QV 243-269 Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents QZ Pathology > QZ 200-380 Neoplasms |
| Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmaceutical Biotechnology Novel Drug Delivery Systems Research Center |
| Page Range: | pp. 611-625 |
| Journal or Publication Title: | Therapeutic Delivery |
| Journal Index: | ISI |
| Volume: | 12 |
| Number: | 8 |
| Identification Number: | https://doi.org/10.4155/tde-2020-0130 |
| ISSN: | 2041-5990 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/14203 |
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