An Algorithmic Approach to Management of COVID-19 Associated Multisystem Inflammatory Syndrome in Children

Abstract

COVID-19 is a viral infection that causes severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In adults, severe respiratory symptoms are the most com- mon clinical presentation (1). Although initial studies suggested that children will experience a mild illness during the acute infection (2), recent studies reported the emergence of a new SARS-CoV-2 infection-related phe- nomenon of a significant hyperinflammatory response in previously healthy asymptomatic children (3). This new phenomenon, termed "multisystem inflammatory syndrome in children (MISC)," has been reported in indi- viduals younger than 19 years. MISC has different clinical presentations, including gastrointestinal problems, mild or absent respiratory symptoms, cardiac disease, rash, and conjunctivitis