Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

Abstract

A systematic review and meta-analysis was conducted to comprehensively examine the association between Dietary Inflammatory Index (DII (R)) score and risk of frailty. Frailty risk were available from five studies comprising 13,908 older adults. Furthermore, frailty related parameters were extacted from two studies with 7,539 individuals. A pooled adjusted odds ratio analysis indicated that there was an association between DII (R) score and frailty risk (OR = 1.24, 95CI: 1.6-1.33, P < 0.001, I-2= 0.0). The results of frailty related parameters demonstrated that DII (R) score was associated with weakness risk (OR = 1.12, 95CI: 1.05-1.19, P = 0.014, I-2= 0.0), but not other frailty-related parameters including exhaustion, low BMI or low physical activity. The results of this meta-analysis suggest that older adults who exhibit higher DII (R) scores have an increased frailty risk. Further prospective cohort studies with longer follow-up periods, are needed to support this possible association between DII (R) score and frailty risk.