The efficiency of gnrh antagonist (cetrotide) in comparison of cabergoline in the prevention and treatment of ovarian hyperstimulation syndrome

Abstract

Background: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic disease that is related to ovarian stimulation by assisted reproduction technology and other infertility treatments. The aim of this study was to determine the effect of GnRH antagonist and cabergoline (Dostinx) on the treatment of ovarian hyperstimulation syndrome in women exposed to this syndrome. Methods: In this quasi-experimental study conducted in Shahid Beheshti hospital in Isfahan, Iran, in 2020, 30 infertile women treated with in vitro fertilization (IVF) were randomly divided into two groups; the first group was treated with steroids and the second group with cabergoline. Age, body mass index, total dose of prescribed gonadotropin, number of oocytes and estradiol level, length of hospital stay, and severity of ovarian hyperstimulation symptoms were determined and compared between the group. Results: The frequency of ovarian hyperstimulation syndrome in each group was 2 cases (13.33). Besides, the amount of injected gonadotropin, number of eggs removed, estradiol level, length of hospital stay and paracentesis were not significantly different between the two groups (P > 0.050 for all). Conclusion: According to the results of the present study, the effect of cabergoline and cetrotide in preventing the occurrence and severity of ovarian hyperstimulation syndrome, length of hospital staying, and the need for paracentesis are similar, and there is no preference in using any of these drugs. © 2021 Isfahan University of Medical Sciences(IUMS). All rights reserved.