Association between neck and wrist circumferences and cardiometabolic risk in children and adolescents: The CASPIAN-V study

Abstract

Objective: The predictive potentials of neck and wrist circumferences for cardiometabolic risks in children and adolescents remain to be determined. The aim of this study was to evaluate the association of neck and wrist circumferences with some cardiometabolic risk factors in children and adolescents. Methods: This multicenter study was conducted during the 2014 to 2015 school year with 4200 children and adolescents ages 7 to 18 y. The children were selected by multistage cluster sampling from 30 provinces of Iran. Anthropometric indices (neck, wrist and waist circumference, and body mass index), biochemical and clinical parameters were measured. Metabolic syndrome was defined based on the Adult Treatment Panel III criteria modified for the pediatric age group. High total cholesterol, high low density lipoprotein cholesterol, and obesity were included as other cardiometabolic risk factors. Results: The participation rate for blood sampling was 91.5 (n = 3843). The mean (standard deviation) age of participants was 123 y (3.2 y). In a multivariate model, neck and wrist circumferences had significant association with elevated blood pressure, low high-density lipoprotein cholesterol, increased body mass index (overweight, excess weight, and generalized obesity), abdominal obesity, and metabolic syndrome. Additionally, obesity had the strongest associations with neck (odds ratio,1.48; 95 confidence interval, 1.45-1.51) and wrist circumference (odds ratio, 2.25; 95 confidence interval, 2.15-236). Conclusion: Neck and wrist circumferences are associated with some cardiometabolic risk factors. They could be used as alternative clinical tools and easy-to-use indicators of cardiometabolic risk in children and adolescents. (C) 2017 Elsevier Inc. All rights reserved.