Antimicrobial resistance properties of Helicobacter pylori strains isolated from dental plaque and saliva samples

Abstract

Background: It is likely that oral cavity, particularly dental plaque and saliva samples, may represent an important reservoir of H. pylon infection for gastric infections. The present research was performed to assess the distribution and antimicrobial resistance of H. pylori strains in dental plaque and saliva samples. Methods: total of 80 H. pylori strains were isolated from dental plaque (n= 42) and saliva (n= 38) samples of patients referred to the Dental Clinic of the Armenia for routine check-ups. H. pylori was isolated using culture. Antimicrobial resistance was determined using cisk diffusion. Results iwenty-two out of 80 (27.50) examined specimens were positive for H. pylori. H. pyloriori prevalence amongst dental plaque rid saliva samples was 33.33 and 21.05, respectively (P <0.05). H. pylori strains harbored the high prevalence of resistance against ampicillin (77.27), amoxicillin (72.22), erythromycin (68.18), and tetracycline (68.18), Resistance rate toward metronidazole was lower than other antimicroblals (40.90). Conclusion: The role of dental plaque and saliva samples as H. pylori reservoirs was determined. Due to the high antimicrobial resistance of isolates against ampicillin, amoxicillin, erythromycin, tetracycline, and even metronidazole, there is a big demand for substitute antimicrobials for the oral colonized H. pylori.