Evaluation of the serum level of osteoprotegerin and bone mineral density in postmenopausal women

Abstract

OBJECTIVES: Women might face different issues after menopause. Reduction in bone mineral density (BMD) is one of these problems that put a heavy burden on the healthcare system, especially in developing countries. Studies assume that along with increased age, lack of physical activity and hormonal issues, some other factors might take part in this process. Osteoprotegerin (OPG) is one of the assumed factors. Here we aimed to assess the relation between serum levels of OPG and BMD in postmenopausal women. METHODS: In this prospective cross-sectional study, 90 postmenopausal women were entered. Our cases were divided based on former medical documents into two groups of osteoporotic women (n=45) and healthy women (n=45). All cases were then analyzed using Dual-energy X-ray absorptiometry (DXA) and BMD and T-score were assessed for each case in different sites. Serum levels of OPG were also assessed using Enzyme-linked immunosorbent assay (ELISA). Data were then analyzed using SPSS software. RESULTS: There were higher OPG levels in osteoporotic women compared with healthy women (P<0.001). We also indicated a significant difference in BMD between two groups of postmenopausal women in different sites (i.e. lumbar vertebrae L2-L4, trochanters, femoral neck and hip). We showed there is a reverse relation between serum OPG levels and BMD in lumbar vertebrae (r=-0.4, P=0.002), hip (r=-0.3, P=0.03) and femoral neck (r=-0.3, P=0.02) in both groups. There is a reverse relation between BMD and serum levels of OPG in postmenopausal women. CONCLUSION: OPG levels are higher in osteoporotic women and have a reverse relation with BMD.