Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite

Abstract

This study synthesized a La(2)O(3)@snowflake-like Cu(2)S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studies, the electrocatalytic diclofenac and chlorzoxazone oxidations on the electrode modified with La(2)O(3)@SF-L Cu(2)S composites were increased, with greater oxidation currents, as well as the oxidation potential was significantly decreased due to synergetic impact of La(2)O(3)@SF-L Cu(2)S composites when compared with the pure SF-L Cu(2)S NS-modified electrode. The differential pulse voltammetry findings showed wide straight lines (0.01-900.0 μM) for La(2)O(3) NP@SF-L Cu(2)S NS-modified electrode with a limit of detection (LOD) of 1.7 and 2.3 nM for the detection of diclofenac and chlorzoxazone, respectively. In addition, the limit of quantification was calculated to be 5.7 and 7.6 nM for diclofenac and chlorzoxazone, respectively. The diffusion coefficient was calculated to be 1.16 × 10(-5)and 8.4 × 10(-6) cm(2)/s for diclofenac and chlorzoxazone oxidation on the modified electrode, respectively. Our proposed electrode was examined for applicability by detecting diclofenac and chlorzoxazone in real specimens.