Association between sleep duration and early pubertal timing in children and adolescents: A systematic review and meta-analysis

Abstract

BACKGROUND: Early puberty increases the risk of diverse health outcomes during adolescence and beyond. Several studies have explored the links between short sleep duration and early puberty worldwide. OBJECTIVE: The current systematic review and meta-analysis aimed to evaluate the association between sleep duration and early pubertal timing based on published evidence systematically. Methods We searched important electronic databases for articles that reported the association between childhood sleep duration and puberty timing up to October 2020. A total of 848 papers were identified from the databases and manual search. Finally, 10 studies including 23752 participants were included in the meta-analysis. We used the STROBE checklist to assess the quality of the included studies. We calculated the pooled effect sizes using a random or fixed effects model as appropriate. Results Ten studies were eligible for this meta-analysis. There was an inverse significant association between sleep duration and the risk of early puberty, longer duration of sleep was associated with 0.34 decreased odds of early puberty (OR = 0.66, 95 CI = 0.58-0.77, I2 = 96.6). In a subgroup analysis, when pubertal status was assessed by physical examination compared with Pubertal Development Scale (PDS) or Sexual Maturation Scale (SMS), the associations between sleep duration and age of puberty were attenuated. The pooled OR (95 CI) of studies measuring pubertal timing by PDS/SMS and Tanner stage were 0.50(0.37-0.69) and 0.91(0.77-1.09) respectively. In the subgroup analysis by BMI levels, the pooled OR (95 CI) was slightly attenuated 0.95(0.89-1.01). Conclusions Longer sleep duration is associated with a lower risk of early puberty in children. The association between sleep duration and risk of early puberty may be modified by other factors such as BMI. To clarify the effect of sleep duration on the risk of early puberty in children, further prospective studies are needed.