Efficacy of Long-Acting Octreotide on Reducing Mucus Production in Patients With Ileal Neobladder

Abstract

PURPOSE: To evaluate the efficacy of long-acting-release octreotide (trade name Sandostatin) on decreasing mucus secretion, thus reducing catheter obstruction after radical cystectomy and orthotopic reconstruction. PATIENTS AND METHODS: In this double-blind, placebo-controlled study, we treated 73 cases of radical cystectomy between the years 2008 and 2014; 65 were deemed eligible for the study. Cases were randomly divided into 2 groups. Group A (n = 32) received 2 doses of 20 mg intramuscular long-acting-release octreotide 4 weeks before and on the day of surgery, while group B (n = 33) received placebo. Catheter irrigation was only performed when there was an obstruction due to a mucus plug. The need for catheter irrigation and the volume of mucus produced by the neobladder were evaluated and compared between the 2 groups. RESULTS: The average number of neobladder irrigations required to treat mucus plugs was 2.3 +/- 1.5 in group A and 9.5 +/- 4.3 in group B (P < .001) before hospital discharge. This number changed to 2.5 +/- 1.5 versus 11.4 +/- 2.7 in groups A and B, respectively (P < .001), after discharge from the hospital. The 24-hour mucus production at the end of the first week was 5.4 +/- 2.7 mL versus 21.5 +/- 5.6 mL in groups A and B, respectively (P < .001). At the end of the third week, this amount changed to 5.5 +/- 2.3 mL versus 21.8 +/- 5.6 mL in groups A and B, respectively (P < .001). CONCLUSION: Two injections of long-acting-release octreotide can dramatically reduce mucus production and hence catheter obstruction due to mucus plugs after radical cystectomy and orthotopic reconstruction.