Inter-subject Registration-based Segmentation of Thoracic-Abdominal Organs in 4 Dimensional Magnetic Resonance Imaging

Abstract

4 Dimensional Magnetic Resonance Imaging (4D MRI) is currently gaining attention as an imaging modality which is able to capture inter-cycle variability of respiratory motion. Such information is beneficial for example in radiotherapy planning and delivery. In the latter case, there may be a need for organ segmentation, however 4D MRI are of low contrast, which complicates automated organ segmentation. This paper proposes a multi-subject thoracic-abdominal organ segmentation propagation scheme for 4D MRI. The proposed scheme is registration based, hence different combinations of deformation and similarity measures are used. For deformation we used either just an affine transformation or additionally free form deformation on top of an affine transform. For similarity measure, either the sum of squared intensity differences or normalised mutual information is used. Segmentations from multiple subjects are registered to a target MRI and the average segmentation is found. The result of the method is compared with the ground truth which is generated from a semi-automated segmentation method. The results are quantified using the Jaccard index and Hausdorff distance. The results show that using free form deformation with a sum of squared intensity differences similarity measure produces an acceptable segmentation of the organs with an overall Jaccard index of over 0.5. Hence, the proposed scheme can be used as a basis for automated organ segmentation in 4D MRI.