Impacts of Fc gamma RIIB and Fc gamma RIIIA gene polymorphisms on systemic lupus erythematous disease activity index

Abstract

Objective: Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fc gamma receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within Fc gamma RIIB and Fc gamma RIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population. Results: Our findings indicated TT and GG genotypes were the common genotypes of Fc gamma RIIB and Fc gamma RIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of Fc gamma RIIB and Fc gamma RIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of Fc gamma RIIB and Fc gamma RIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P < 0.001-0.5).