Therapeutic effects of Quercus persica l fruit skin on healing of second-degree burn wounds in animal model

Abstract

Background and Objective: Second-degree burns are associated with several complications such as infection, septicemia, and unpleasant skin appearance and are one of the main causes of in-hospital mortality. Therefore, this study was designed to determine the therapeutic effects of Q. persica fruit skin on the healing of second-degree burn wounds. Materials and Methods: In this experimental study, 60 mice were randomly assigned into three groups. Vaseline was used for group 1, 1 Silver sulfadiazine (SSD) cream was used for group 2, and Vaseline-based Quercus persica L. hydroalcoholic extract was used for group 3. After the development of second-degree burns with a pathologist’s confirmation, the wound area was measured for a month by AutoCAD software. The wound was pathologically examined and data were analyzed by repeated measures ANOVA and Kruskal-Wallis using SPSS 18. Results: Decrease in wound area was 72.01 in the Quercus persica L. group, 65.95 in the SSD group, and 59.12 in the Vaseline group. Mean wound recovery was higher in the Q. persica fruit skin group but not significant (P>0.05). The mean number of wound hair follicles and sebaceous glands and mean wound angiogenesis were higher while wound inflammation intensity was lower in Quercus persica L group, but no significant difference in these variables was seen between the Quercus persica L and SSD groups (P>0.05). Conclusion: Quercus persica L. had relatively acceptable therapeutic effects on the healing of second-degree burn wounds compared to SSD and Vaseline. © 2017, Zanjan University of Medical Sciences and Health Services. All rights reserved.