Cyclooxygenase-2 expression in squamous cell carcinoma of the head and neck

(2017) Cyclooxygenase-2 expression in squamous cell carcinoma of the head and neck. Journal of Isfahan Medical School. pp. 1038-1043. ISSN 10277595 (ISSN)

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Abstract

Background: Cyclooxygenases-2(COX) expression in cancer tissues is associated with worse prognosis of cancers. We studied cyclooxigenase-2 expression among patients with head and neck squamous cell carcinoma (HNSCC). Methods: In a cross-sectional study performed in two university hospitals in Isfahan City, Iran, between the years 2011 and 2015, patients with newly pathological diagnosis of HNSCC were evaluated. Real-time polymerase chain reaction (real-time PCR) was used to evaluate the expression of cyclooxigenase-2 in surgical excised cancer tissues. Patients were followed-up for one year regarding recurrence and mortality. Association of cyclooxigenase-2 expression with clinicopathologic data and prognosis were analyzed. Findings: Thirty cases of HNSCC with mean age of 59.6 years (70 men) were studied. Only 4 cases (13.3) were cyclooxigenase-2 positive. Compared with cyclooxigenase-2 negative cases, those with cyclooxigenase-2 expression were relatively, but not significantly, older (71.0 ± 12.5 vs. 57.8±12.0 years, P = 0.054) and had larger tumor size (2.70 ± 1.19 vs. 1.76 ± 0.84 cm, P = 0.061), more frequent moderately/poorly differentiated tumors (50.0 vs. 15.3 percent, P = 0.190), and more frequent involvement of the lymph nodes (50.0 vs. 7.6 percent, P = 0.075). One of the cyclooxigenase-2 positive cases had metastasis. After one year follow-up, recurrence rate was 75.0 and 9.5 in cyclooxigenase-2 positive and negative cases, respectively (P = 0.005). Conclusion: We found that cyclooxigenase-2 expression in HNSCC patients is associated with worse clinicopathologic characteristics and prognosis. It may be used as a prognostic factor for HNSCC and also a target for treatment. Further studies with larger sample size are warranted in this regard. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.

Item Type: Article
Keywords: Biological markers Carcinoma Cyclooxygenase Head and neck neoplasms Squamous cell cyclooxygenase 2 Article cancer mortality cancer prognosis cancer recurrence clinical article cross-sectional study follow up head and neck squamous cell carcinoma human human tissue lymph node metastasis multicenter study protein expression real time polymerase chain reaction recurrence risk tumor volume
Divisions: Faculty of Medicine
Faculty of Medicine > Departments of Clinical Sciences > Department of Pathology
Page Range: pp. 1038-1043
Journal or Publication Title: Journal of Isfahan Medical School
Journal Index: Scopus
Volume: 35
Number: 443
ISSN: 10277595 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/1813

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