Comparison of troponin, high-sensitivity troponin, and copeptin markers at different times in patients with high-risk chest pain

Abstract

Background: The incidence of cases with acute myocardial infarction (AMI) and patients suffering from chest pain (CP) referred to emergency departments are increasing. Therefore, finding a marker that can help faster diagnose of the disease can have beneficial effects for patients. This study compared troponin, high-sensitivity troponin, and copeptin markers at different times in patients with high-risk chest pain. Methods: This study was performed on 90 emergency care patients with high-risk chest pain, as the first symptom of myocardial infarction (MI), in educational hospitals in Isfahan City, Iran. Demographic and clinical data including the levels of troponin, high-Sensitivity troponin, and copeptin markers were collected and evaluated at the time of arrival, and 2 and 6 hours later. Findings: The mean age of patients with high-risk chest pain was 60.73 ± 1.23 years, of which 57 (63.3) were men. There were significant differences between the frequency of three markers at arrival (P = 0.0004) and 2 hours (P = 0.0009) later. Nevertheless, after 6 hours, the results did not show any significant difference (P > 0.0010). Conclusion: Repeated measurement of copeptin leads to a more successful AMI prevention compared to troponin and high-sensitivity troponin markers. © 2019 Isfahan University of Medical Sciences(IUMS). All rights reserved.