Effect of aspirin desensitization on nasal polyps recurrence and remission based on imaging studies in patients with triple symptoms of asthma, aspirin sensitivity, and nasal polyps and the impact of this method on their quality of life

Abstract

Introduction: Chronic rhinosinusitis with recurrent nasal polyps, asthma, and allergy to non-steroidal anti-inflammatory drugs (aspirininduced asthma) is a condition that can severely affect patient's quality of life. This study was conducted to determine the effect of aspirin desensitization on nasal polyps recurrence and remission in patients with triple symptoms of asthma, aspirin sensitivity, and nasal polyps. Materials and methods: In this clinical trial, samples consisted of 50 patients with aspirin-induced asthma were selected by Morgan table and were randomly divided into two groups, one case group, and one control group. The control group received no treatment while the case group received aspirin desensitization protocol using an ascending dose of aspirin from 25 mg every three hours to 325 mg under direct supervision. After 3 months, pulmonary examination and imaging test were performed again. The patient's quality of life was investigated before and after treatment using the questionnaire of quality of life (QoL) of polyposis patients. Results: The quality of life in patients with rhinosinusitis (RDS) before and after aspirin desensitization was 48.38 +/- 5.21 and 46.06 +/- 4.85 respectively which was significantly improved (if this result is from another study, author and the year of the study should be written in the sentence, or if this result is from all sample, then it should also be stated in the sentence). In the case group, the quality of life was also improved, with an average score of before and after treatment was 47.32 +/- 6.61 and 42.6 +/- 3.42 respectively (p < 0.001) (the p-value already stated that the result was significant). Meanwhile, the quality of life in the control group was not improved, with average before and after treatment score was 49.44 +/- 2.79 and 49.52 +/- 3.23 respectively (p = 0.9) (the p-value already stated that the result was not significant). Conclusion: Aspirin desensitization leads to improvement of life quality and reduction of rhinosinusitis symptoms in patients with aspirin-induced asthma.