Interleukin-10 and brain-derived neurotrophic factor responses to the Mat Pilates training in women with multiple sclerosis

Abstract

AIMS: To determine the effect of Mat Pilates on serum levels of interleukin-10 and brain-derived neurotrophic factor in women with multiple sclerosis. METHODS: Thirty women with multiple sclerosis with mild to moderate disability were recruited and randomly divided into equal Pilates training and Control groups. Patients in the training group accomplished a Pilates program three times a week for eight weeks. The Control group maintained their routine lifestyle. The serum level of interleukin-10 and brain-derived neurotrophic factor were measured before and after the protocol. The differences between groups were assessed by using analysis of covariance test to compare post-tests by considering covariate pre-tests (assuming a p-value < 0.05 as significant). RESULTS: There were no significant changes in interleukin-10 (13.09 ± 5.36 ng/ml in the Pilates training group compared to 13.21 ± 4.76 ng/ml in the Control group, p = 0.81), whereas an increase in brain-derived neurotrophic factor was observed after eight-week Pilates training (11550.14 ± 2619.60 ng/ml in the Pilates training group compared to 9664.35 ± 3161.66 ng/ml in the Control group, p = 0.03). CONCLUSIONS: The results suggest that the intensity and duration of this protocol was not related to significant changes in interleukin-10, but was followed by an increase in brain-derived neurotrophic factor in these patients. Based on this finding, physical activity according to the individual’s ability is recommended for patients with multiple sclerosis, in parallel with drug therapy. © Copyright© (2018) by DEStech Publications, Inc. All rights reserved.