The preventive effect of donepezil on post-operative cognitive disorder in patients undergoing coronary artery bypass graft (CABG) surgery

Abstract

Background: This article aimed to study the effect of donepezil prescription on the incidence of post-operative cognitive disorder in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: In this double-blind randomized clinical trial study, the statistical population consisted of all candidates for coronary artery bypass graft surgery visiting Chamran hospital, Isfahan, Iran. Convenience sampling was employed and the patients were enrolled according to the order of visiting and inclusion criteria. Data were collected using a questionnaire and psychiatric tests by filling up check lists and conducting interviews. The data were then analyzed using chi-square, t, and Mann-Whitney tests via SPSS software. Findings: The frequency of cognitive disorder development was greater in control group than donepezil group on the first and second days of hospitalization and the differences were significant (P < 0.050 for both). The average number of transfused blood units was not significantly difference between the two groups (P > 0.050). The average number of cryo blood products had a significant difference between two groups after cardiopulmonary bypass (CPB) (P = 0.004). No significant difference was found between the two groups concerning the average pump time, clamping time, duration of surgery, length of stay in intensive care unit (ICU), and length of stay in hospital (P > 0.050 for all). Conclusion: Donepezil significantly declines the cognitive disorder after coronary artery bypass graft surgery. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.