The relationship of acidosis and coagulopathy in patients admitted to intensive care units

Abstract

Background: One of the markers of coagulopathy incidence in critical patients is acidosis that leads to increasing mortality and morbidity rates in patients hospitalized in intensive care unit (ICU). The aim of this study was determining the relationship between acidosis and coagulopathy in patients admitted to the intensive care units. Methods: In a cross-sectional study done in intensive care units of therapeutic and educative centers in Isfahan city, Iran, 120 critical patients were enrolled. The criteria of acidosis and coagulopathy were examined during 14 days and the relationship between intensity of that was determined. Findings: Of 120 patients, 15 suffered from severe acidosis; 2 of them (13.3) had moderate and 13 (86.8) had severe coagulopathy. 20 patients suffered from moderate acidosis that 9 (45.0) had mild and 9 (45.0) had moderate coagulopathy. 23 patients suffered from mild acidosis that 16 (69.6) had mild, 2 (8.7) had moderate, and 5 (21.7) had sever coagulopathy. In addition, of 62 of patients without acidosis, 38 (61.3) had mild and 8 (12.9) had moderate coagulopathy. There was a significant relationship between the intensity of acidosis and the intensity of coagulopathy (P < 0.001). Conclusion: The intensity of acidosis and the intensity of coagulopathy had significant relationship. Total factors of acidosis and coagulopathy had a positive role in patients’ outcomes. So, in patients with acidosis, specially sever intensity, total activity must be done to prevent coagulopathy. © 2017, (publisher Name). All rights reserved.