Association between maternal plasma total antioxidant capacity and dietary antioxidants intake with birth size outcomes

Abstract

Background Maternal antioxidants intake and plasma total antioxidant capacity (TAC) concentration during pregnancy might influence on birth outcomes. This study was conducted to determine the association between dietary antioxidants intake and plasma TAC during pregnancy with birth outcomes. Methods Overall, 220 mother-infant pairs were recruited in the first trimester of pregnancy. Maternal whole blood was collected and TAC was determined by the ELISA kit. Food frequency questionnaire was used to collect information regarding usual dietary intake. Birth size measurements including birth weight, length and head circumference were measured according to standardized protocols. Results Energy-adjusted intake of beta-carotene in the first trimester of gestation beta (SE) = 0.0002 (0.00008); p = 0.016 and energy-adjusted intake of vitamin E in third trimester of pregnancy beta (SE) = -0.31 (0.15); p = 0.046 had significantly positive and negative associations with birth length, respectively. The maternal plasma TAC was positively correlated with birth weight in both unadjusted and adjusted models beta (SE) = 2.75 (1.35); p = 0.043 and beta (SE) = 3.43 (1.50); p = 0.023, respectively. In addition, the adjusted model showed a significant positive relationship between the maternal plasma TAC and birth length beta (SE) = 0.023 (0.009); p = 0.01. Conclusion This study showed the positive association of maternal plasma TAC with birth weight and length. Moreover, maternal dietary intake of beta-carotene in the first trimester and vitamin E in the third trimester of pregnancy had significant positive and negative correlations with birth length, respectively.