Comparing the Efficacy of Dimenhydrinate-metoclopramide, Dimenhydrinate -Ondansetron and Dimenhydrinate Alone on Nausea and Vomiting after Cataract Surgery under Local Anesthesia and Intravenous Sedation

Abstract

Background: The study aimed to compare the efficacy of Dimenhydrinate-Metoclopramide, Dimenhydrinate-ondansetron and Dimenhydrinate alone on nausea and vomiting after cataract surgery under local anesthesia and intravenous sedation. Methods: In this clinical trial study, 160 patients undergoing cataract surgery were divided into four groups of 40. Thirty minutes before induction in the first group (D-M) 0.1mg/ kg metoclopramide + 0.5 mg/ kg Dimenhydrinate, in the second group (D-O) 0.4 mg/ kg ondansetron + 0.5 mg/ kg Dimenhydrinate, in the third group (D), 0.5mg/ kg Dimenhydrinate and in the fourth group (C) 2 cc of distilled water were injected and the incidence and severity of nausea and vomiting at recovery and 2 and 4 hours after surgery and at the time of discharge were evaluated and compared between groups. Findings: The incidence of nausea at recovery in four groups of D-M, D-O, D and C were 13.2, 10.8, 22.2 and 36.1, respectively, and the difference between the groups was significant (P = 0.015). In the next two hours, the incidence of nausea in the four groups was 10.8, 5.3, 22.2 and 27.9, respectively (P = 0.035). The incidence of vomiting in recovery was 16.2, 7.9, 16.7 and 33.3 among the four groups, respectively (P = 0.039). Also the intensity of nausea in recovery were statistically different between 4 groups and the Dimenhydrinate-ondansetron group had the least severity of nausea. Pain intensity was lower in Metoclopramide receiving group. Conclusion: Dimenhydrinate-ondansetron combination compared with Dimenhydrinate-metoclopramide and Dimenhydrinate alone led to an increased reduction of postoperative nausea and vomiting following cataract surgery. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.