Evaluation of the Associations between Dry Mouth, Oral Lesions, and Orofacial Pain with COVID-19: A Systematic Review and Meta-analysis

Abstract

Objectives: In patients with periodontal disease, the risk of COVID-19 is very high, so it is important to check oral health. Because the clinical manifestations of COVID-19 disease are not fully understood and the relationship between severity, mortality, and oral health is challenging, in the present study, we tried to investigate the relationship between clinical outcomes and COVID-19. Therefore, the present study evaluated the associations between the dry mouth, Oral lesions, and Orofacial pain with COVID-19. Methods: The present study is based on PRISMA guidelines; all articles were published in international databases such as PubMed, Scopus, Science Direct, and Embase between March 2019 and May 2022. 95 confidence interval for effect size with random effect modal and REML were calculated. Meta-analysis of data collected from selected studies was performed using STATA.V16 software. Results: In the initial review, the abstracts of 312 studies were reviewed, two authors reviewed the full text of 36 studies, and finally, 16 studies were selected. The prevalence of dry mouth and oral lesions in patients with COVID-19 was 39 (ES: 95 CI, 32 to 46) and 32 (ES: 95 CI, 22 to 42), respectively. Conclusions: The prevalence of dry mouth in patients with COVID-19 was higher (39) than oral lesions (32) and orofacial pain (23). © 2022 Wolters Kluwer Medknow Publications. All rights reserved.