Fabrication and Characterization of a Novel Wound Dressing with Clindamycin Loaded PVA Nanoparticles for Acne Treatment

Abstract

Acne vulgaris is the most common skin disorder that may cause constant scarring on the face. Conventional methods for acne treatment have various side effects such as inflammation, dryness, peeling, cutaneous irritation and scaling of the skin. The novel wound dressing coated with nanoparticles containing drug was fabricated as a drug delivery system for acne treatment. In this present, Polyvinyl alcohol (PVA) nanoparticles containing clindamycin were successfully prepared by the electrospraying method and coated on the surface of cotton fabric. The final drug loaded nanoparticles were characterized using Field-emission scanning electron microscope (FE-SEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD), Differential scanning calorimeter (DSC) and biodegradation. The increasing clindamycin concentration in electrospraying solution led to reverse effects on the viscosity, electrical conductivity and affect on the diameter of nanoparticles. At various concentrations of clindamycin, spherical nanoparticles with uniform size were formed from PVA solution. Also, drug release rate was investigated using both in vitro dissolution and permeation methods during 720 min. Fractional release curves obtained exhibited short term release of clindamycin within first 60 min and slower release rate until 720 min. The release rate of clindamycin was higher from PVA nanoparticles containing 10 W/W drug than those loaded with 5 W/W drug. Release plots were analyzed based on Korsmeyer-Peppas model, suggesting Fickian diffusion as the dominant clindamycin release mechanism from the PVA nanoparticles. Moreover, the drug release profile of PVA nanoparticles coated cotton fabric was found to be lower than that for the drug loaded nanoparticles. This study suggests wound dressing coated with PVA nanoparticles as a novel drug delivery vehicle for short term administration of clindamycin for treatment of acne scars.